2012 - Management of Anaphylaxis

2012 - Management of Anaphylaxis - Management of...

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Management of anaphylaxis Because the symptoms of anaphylaxis may progress rapidly and become life-threatening, it is important that treatment be initiated promptly. 1 Immediate intervention tactics involve assessing airway, breathing, circulation, and level of consciousness as well as administering epinephrine. 1 Epinephrine as the cornerstone of emergency treatment for anaphylaxis During anaphylaxis, epinephrine has potent lifesaving alpha-1 adrenergic vasoconstrictor effects on the precapillary sphincters and small arterioles in most body systems, decreasing mucosal edema and increasing blood pressure (Figure 1). The combined effect of its vasoconstriction properties is to relieve upper airway obstruction and prevent and relieve shock. Epinephrine also has beta-1 adrenergic effects, which increase the rate and force of cardiac contractions, as well as beta-2 adrenergic effects, which increase bronchodilation and decrease release of histamine, tryptase, and other inflammation mediators from mast cells and basophils (Figure 1). 2-4 When should epinephrine be administered? Prompt injection is important, as delayed injection of epinephrine is associated with fatal anaphylactic reactions.
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  • Fall '13
  • MargaritaDiVall
  • Mast cell, Allergy Clin Immunol.

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