Notes Principles of Biology Immune SYSTEM 4

Notes Principles of Biology Immune SYSTEM 4 - Notes...

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Notes Principles of Biology 02/12/14 The Immune System Tuberculosis (TB) White plague of the 17 th - 19 th centuries (caused ~25% of adult deaths) M. tuberculosis DNA recovered from Egyptian mummies (and probably much older) Cases of tuberculosis have decreased Bacteria becomes resistant to many antibiotics World TB incidence 2 million deaths every year 2 billion people infected (5-10% could develop disease) The two stages of TB Primary stage=exposure, mild disease (but bacterium persists in infected macrophages) Secondary stage=after a span of months or years (especially if immune system is weakened) Symptoms of TB Necrosis of the lungs X-rays reveal destroyed lung tissue Adaptive (acquired) immunity Develops after exposure to microbes or toxins Very specific response
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Unformatted text preview: ( large repertoire of receptors) • Keeps memory of pathogen Adaptive immunity • Relies on two types of lymphocytes • T lymphocytes =mature in the t hymus • B lymphocytes= mature in the b one marrow • Antigens (Ag) =substances that can elicit a response from a lymphocyte (B or T cell) Antigen receptors • The small part of an antigen that binds to an antigen receptor is called an epitope • Diversity: each individual lymphocyte is specialized • to specifically recognize one epitope • Epitopes bind to antigen receptors Antigen recognition by B cells • Antigen receptor in a B-cell is a Y-shaped molecule with • two identical heavy chains and two identical light chains • The variable (v region) regions provide antigen specificity...
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  • Spring '14
  • Eichenberger
  • Biology, DNA, antigen receptors, antigen receptor, World TB incidence

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