Notes Principles of Biology Immune System 3

Notes Principles of Biology Immune System 3 - Notes...

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Notes Principles of Biology 02/12/14 The Immune System Natural killer cells Differentiate and mature in the lymphatic system (lymphocyte) Not phagocytic Release chemicals leading to cell death Inhibit the spread of virally infected or cancerous cells Human lymphatic system= Network that distributes a fluid called lymph Complement system =Group of ~30 proteins in blood plasma helps trigger inflammation facilitates phagocytosis causes cell lysis Complement system proteolytic cascade generates ~ 30 proteins Membrane attack complexes (MACs) Complement peptides promote microbial cell lysis by formation of holes in membranes MACs inserted into the membrane of red blood cells Assemble in memebrane in pathogen. leads to lysis of cell Evasion from innate immunity
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Unformatted text preview: Various mechanisms • Two examples of persistence after phagocytosis: • Listeria monocytogenes (listeriosis) • Mycobacterium tuberculosis (tuberculosis) • Bacteria and infectious agents have adapted. . (2 examples) • Pregnant woman shouldn’t have cheese? • 2 stages of tuburculosis (primary, then secondary stage) Immune evasion by lysis of phagosome • Pore formation in the phagosome by LLO (listeriolysin O) = protein expressed by the pathogen • High temperature (37 degrees) + food = good conditions • Actin-dependent movement • Uses host actin for movement • (bacterium only provides the anchor site, ActA) • Will move from cytoplasm to cytoplasm • Actin act A • Bacteria can manipulates hosts resources...
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  • Spring '14
  • Eichenberger
  • Biology, 37 degrees, cell lysis, microbial cell lysis

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