Notes Principles of Biology immune system 1

Notes Principles of Biology immune system 1 - Notes...

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Notes Principles of Biology 02/10/14 The Immune System The role of the immune system is to eliminate pathogens The immune system recognizes and responds to Pathogens =agents that cause disease (usually microbes or toxins) Two types of responses: innate immunity adaptive immunity One you encounter pathogen, you are protected against it from happening again. (vaccines adaptive immunity) Innate immunity Present before any exposure to pathogens Non specific responses Recognition of traits common to groups of pathogens (requires only a small set of receptors) First, rapid, response to infections Barrier differences that are present before any exposure of pathogen Innate immunity is found in all animals and plants All animals : Barrier defenses: (e.g skin) Chemical defenses (e.g. antimicrobial peptides)
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Unformatted text preview: • Cellular defenses (e.g. phagocytosis) • Unique to vertebrates: • Inflammatory response • Natural killer cells • Interferons (inhibition of viral infections) • Skin is first-line defense • Immunity is found in every living organism • Whenever there is an action, there is a response. Barrier defenses in humans • Body fluids (saliva, tears, mucus) • Skin Mucous membranes • of the respiratory, urinary, and reproductive tracts • Low pH (acidity) of skin and the digestive system PRMs: p attern r ecognition m olecules • Toll-Like Receptors (TLRs) • (usually found on phagocytes) • Usually leads to creation of cytokines (hormones of immune system) • One TLR recognizes DNA another recognizes RNA • This one recognizes CpG DNA •...
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  • Spring '14
  • Eichenberger
  • Biology

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