Bio 1001 Lecture 8 Notes

Bio 1001 Lecture 8 Notes - Bio 1001 Tom Haffie LECTURE 8...

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Bio 1001 Tom Haffie LECTURE 8 Terms Centrosome = Microtubule organizing center (animals) = Spindle Pole BODY --> makes spindle (poles) Centromere --> connects homologues Cohesin: protein complex holding together sister chromatids Synaptonemal complex: protein complex holding together 2 homologues Mitosis 1. Prophase - DNA condenses into chromo 2. Prometaphase (late pro) - nucl. envelope breaks down --> spindle attaches to kinetochores of both sis. chromatids 3. Metaphase - chromo moved to midline --> tug-o-war tension triggers 4. Anaphase - Sister chromatids separated --> 2 chromosomes --> "climbing" the spindle poles to opp. ends 5. Telophase/cytokinesis - cell memb. pinches inward --> 2 cells, nuclear envelope
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Unformatted text preview: form, chromo. uncondensed Cytoskeleton Spindle must attach from opposite sides to both kinetochores --> brings to midline o Each sister chromatid has a kinetochore, motor proteins climb up spindle poles --> segregates chromatids 1) Microfilaments = actin-> cytokinesis; 2) Microtubules = tubulin-> spindle + shape; 3) Intermediate fil.=keratin-> shape Check Points- ensure inheritance of sameness 1. G 1 checkpoint: repair damage + decide to go into G 2. G 2 checkpoint: ensure its ready for mitosis 3. Spindle assembly Checkpoint: won’t enter anaphase until all chromsomes connected and at midline o Prevents aneuploidy by preventing disjunction Location? Implications of malfunctioning components?...
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  • Fall '12
  • HAFFIE
  • Biology, Mitosis, Microtubule Organizing Center, spindle assembly checkpoint, Tom Haffie, (poles), Spindle Pole BODY

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