Bio 1001 Lecture 2, 3, 4 Notes

Bio 1001 Lecture 2, 3, 4 Notes - Bio 1001 Tom Haffie...

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Bio 1001 Tom Haffie LECTURE 2 Distribution and Mechanism of HIV Sub-Saharan Africa --> pop. In contact with animals HIV is a retrovirus, uses: 1. Reverse transcriptase --> many errors, no 3'OH proof reading DNA pol 2. Intergrase --> becomes part of genome difficult to attack without collateral to cell --> target HIV specific stages o Immune system attack: Macrophage --> factory (buds out); T-cells --> ruptured Viruses Evolve Rapidly HIV Mutates vigorously if not eliminated: Variation, Heritability, Differentiated reproduction, Genotype change o Reason why AZT efficiency decrease overtime --> cocktail approach New influenza strain each year (yr. vaccination) o Like bacteria that can carry antibiotic resistant genes in transposons CCR5 [ 公式 ]32 Allele --> Homo [ 公式 ]immune; Hetero = resistance Northern Europe -->HIV uncommon --> unlikely allele developed due to resistance (lacked time) o Chance mutation (SNPs) Vs. allele function in evolutionary past (bubonic plague?) LECTURE 3 Characteristics shared by life
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