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Unformatted text preview: to find receptors inside the cell. Water Soluble : Amine and polypeptide hormones are hydrophilic and, because they cannot cross the cell membrane , act via second messengers. Hormone Transport in Blood • Protein hormones circulate in free form in blood • Steroid (lipid) & thyroid hormones must attach to transport proteins synthesized by liver – improve transport by making them water-soluble – slow loss of hormone by filtration within kidney – create reserve of hormone General Mechanisms of Hormone Action • Hormone binds to cell surface or receptor inside target cell • Cell may then – synthesize new molecules – change permeability of membrane – alter rates of reactions • Each target cell responds to hormone differently – liver cells---insulin stimulates glycogen synthesis – adipose---insulin stimulates triglyceride synthesis...
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- Spring '14
- Endocrine System, Anatomy & Physiology II