1min borneol percent isoborneol conversion

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Unformatted text preview: oximatelya92%yieldandformsaproductmixof84.56%isoborneoland15.44%borneol.Inthe MPVreaction,productsinterconvertbetweenoneanothercontinuouslyunderconstantreaction conditions,eventuallyreachingthermodynamiccontrol.Whencamphorisreactedincumeneunder refluxconditionsinstandardatmosphericpressureforoveranhourandahalfwithAl(OPri)3,itreaches afinalproductratioof2.47molsBorneolto1molisoborneol,witha97%conversion.Thereactionwas calculatedtohaveakeqof~2.5  ­0.7kJ/mol.  Experimental NaBH4ReductionofCamphor Benzaldehyde(0.26mL,2.5mmol)wasdissolvedin methanol(3.0mL)inaflaskatopahotplatewithastirbaradded.Tothissolution,whilestirring andheatingto90°C,NaBH4(0.313g,8mmol)wasadded,andawater ­cooledcondenserwas affixedtotheneck.Additionalmethanol(3.0mL)wasaddedtocompensateforthelargeamount ofwhiteprecipitateformedbythereaction.Afterallowingeverythingtore ­dissolve,isoborneol (0.383g,2.5mmol)wasaddedtothereactionmix,andthesolutionwasrefluxedfor15minutes. ThereactionmixturewasallowedtocooltoroomtemperaturebeforedeionizedH2O(10mL) wasadd...
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This document was uploaded on 03/27/2014 for the course BIO 403 at Rochester.

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