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KIN 405 Lecture 1 and 2

atherosclerosis highxdensitylipoproteinhdlcholesterol

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Unformatted text preview: %betaXadrenergic%receptors% •  Sympathe:c%nerve%inhibitors%–%prevent%arteriole% constric:on% •  Vasodilators%–%induce%relaxa:on%in%arterial% smooth%muscle% •  %ACE% inhibitors %–%%↓%arteriole%constric:on%by% %% disrup:ng%angiotensin%produc:on% •  Calcium%channel%blockers%–%reduce%heart% contrac:lity% Lowering%Blood%Pressure% NonOpharmacological$ •  SodiumXrestricted%diet% •  Weight%loss% •  Restricted%alcohol%intake% •  %Exercise % %% %% 5.%Dyslipidemia% % •  Abnormal%blood%lipid%profile%any%of%the%following:% –  % higher %than%normal%levels%of%total%cholesterol% %% –  % %higher %than%normal%LDL%cholesterol%% % –  % %lower %than%normal%HDL%cholesterol%% % –  higher%than%normal%triglyceride%levels%% •  Metabolic%disorder%that%is%secondary%to%many%diseases% including%atherosclerosis%and%cardiovascular%disease% Cholesterol%and%Triacylglycerides% LowXdensity%lipoprotein%(LDL)%cholesterol%% •  "bad"%cholesterol% •  %%high %levels%in%blood%can%s:mulate%plaque%(faUy%deposits)% % forma:on%in%blood%vessel%walls%!% atherosclerosis% %% %%% % HighXdensity%lipoprotein%(HDL)%cholesterol%% •  "good"%cholesterol% •  Helps%carry%% LDL %away%from%blood%vessel%walls%and% % removing%it%from%body% % Triacylglycerides%% •  Most% common %fat%in%our%bodies% %% •  Food%intake:%increase%risk%of%blood%clots% % Key%Secondary%Causes%of% Dyslipidemia% •  Diet:% saturated fat % %and%cholesterol%in%food%% %%% •  Weight:%Being%overweight%tends%to%increase%your% cholesterol%!%par:cularly % abdominal % besity %% %%o% •  Physical%%Inac:vity:%Regular%exercise%can%help% lower % % %LDL%(bad)%cholesterol%&% raise% %HDL%(good)% % cholesterol%levels.%% •  Others:%Kidney%disease%(nephro:c%syndrome),% hypothyroidism,%anorexia%nervosa,%family%history% Lipid%Profile%Measurements% •  Include:%total%blood%cholesterol,%LDL%cholesterol,%HDL% cholesterol,%triacylglycerides%% Canadian%2003%guidelines%recommend%regular%tes:ng%for:% •  Males% >40 %years%of%age%% % •  Females% >50 %years%of%age%and%/%or%postXmenopaus...
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