KIN 405 Lecture 1 and 2

Presentinagingcertainillnessesorwhensedentary

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Unformatted text preview: nal)regula9on)of) lipolysis)) ! ! J#P!Deprés!and!I!Lemieux!Nature!444:881,!2006$ Sarcopenia !  Sarcopenia)=) loss of muscle; low muscularity; in eldery !  Muscle)is)an)important)regulator)of)glucose,)lipid)and) protein)metabolism) Sarcopenic Obesity : ‘double-wammy’ !  Increased)fat)depots)results)in)impairments)of)various) organs)including) MUSCLE ) ) )) !  Present)in)aging,)certain)illnesses)or)when)sedentary)&) gaining)weight)) !  Increased)risk)of)simultaneous)loss)of)muscle)and)gain)of) fat)9ssue)=)% SARCOPENIC OBESITY Obesity%–%Current%Solu:ons%% •  Nutri:on%&%Exercise%Programs% •  Bariatric%Surgery% –  hUp://www.cbc.ca/news/background/obesityX surgery/% –  hUp://www.cbc.ca/news/background/obesityX surgery/sharmaXtranscript.html%% Obesity% •  •  •  •  hUp://www.corecanada.net/% discussion%of%the%latest%research%in%obesity% hUp://www.corecanada.net/?page_id=503“% Central%theme%of%the%discussion%centres% around%% –  How%much%is%enough%exercise%to%prevent%or% control%chronic%disease?% –  What%are%the%appropriate%recommenda:ons?% 2.%Diabetes% TYPE)1)DIABETES% •  beta%cell%destruc:on%by%autoimmune%processes,% leading%to % insulin d%eficiency% %% % % •  usually%develops%in%childhood%or%adolescence%% •  Affects% 10% %of%people%with%diabetes) % ) TYPE)2)DIABETES% •  characterized%by%varying%degree%of% insulin resistance %%%%% %and%rela:ve %insulin d%eficiency %% % %% •  usually%occurs%later%in%life%% •  Affects% 90% %of%people%with%diabetes% % % Diabetes% Fas:ng% Normal% Impaired%Glucose% metabolism% Type%2%diabetes% Oral%glucose% tolerance%test% <6.0%mM% <7.8%mM%at%2%hr% 6.0X7.0%mM% 7.8%X11.0%mM%at%2%hr% >%7.0%mM% >%11.1%mM%at%2%hr% •  Gestational diabetes: –  temporary condition that occurs during pregnancy –  affects ~3.5% of all pregnancies –  increased risk of developing diabetes for both mother & child http://www.diabetes.ca/section_about/index.asp Is%Diabetes%Serious?% If%lep%untreated%or%improperly%managed,%diabetes% can%result%in%a%variety%of%complica:ons,%including:%% •  Heart%disease%% •  Kidney%disease%% •  Eye%disease%% •  Problems%with%erec:on%(impotence)%% •  Nerve%damage%% •  Damage%is%related%to%glyca:on%of%proteins%in%the% basement%membrane%and%damage%to%endothelial% cells.%%% Diabetes%Risk%Factors% •  Ethinic)Background:)Aboriginal,)Hispanic,)Asian,)South)...
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This document was uploaded on 03/28/2014 for the course KIN 405 at Waterloo.

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