KIN 405 Lecture 1 and 2

Esleepapnea mskdisordersegosteoarthris

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Unformatted text preview: y as body fat (TAG) Health%Consequences%of%Obesity% •  •  •  •  •  •  •  •  Cardiovascular%disease% Diabetes% Some%forms%of%cancer% Hypertension%(high%blood%pressure)% Gall%bladder%disease% Reproduc:ve%problems% Sleep%disorders%i.e.%sleep%apnea% MSK%disorders%e.g.%Osteoarthri:s% http://www.obesitycanada.com/index.php Central%vs.%Peripheral%Obesity% % % % % % % %X%fat%deposi:on%principally% over%the%abdomen%and%upper%body% (android)% Central Obesity (Apple) % Peripheral Obesity (Pear)%–%fat%distribu:on%is%more% %% % % % % peripheral,%open%around%the%hips%&%gluteal% region%(gynoid)% Abdominal%Obesity% •  Waist%circumference%can%be%an% indicator%of%abdominal%obesity%and% disease%risk,%in%addi:on%to%BMI%% >88cm %%%%( >102cm %for%M;%%%%%%%%%%%%%%for%W).% = higher risk %% •  Waist%to%hip%ra:o%can%also%be%used,% but%waist%circumference%appears%to% be%a%beUer%prognos:c%marker% •  4%compartments: visceral retro (behind kidneys) % % %,% retroperitoneal,%subcutaneous%&% intramuscular% Shuster%et%al%Bri:sh%Journal%of%Radiology%85(1009):1X10,%2012% % % % Abdominal% % %Obesity% %% %% •  CT%and%MRI%analysis%quan:fy%abdominal%fat%and%dis:nguish% between%%visceral %and%subcutaneous%fat.% % •  Fat%in% abdominal %region%associated%with%greater%health%risks% % % than%fat%in%peripheral%regions.% •  Presence%of% increase total abdominal%fat%appears%to%be%an% % % % % independent%risk%predictor%even%when%the%BMI%is%not% markedly%↑% •  Decrease%in% visceral% % %adiposity%with%exercise%can%reduce% these%risks%(Ross%R%et%al%Ann%Intern%Med%133(2):92X103,%2000) **% % % Visceral%Obesity%% •  Visceral)Adipose)Tissue)is)more)metabolically) ac9ve) •  Linked)to)accelerated)mobiliza9on)of)faVy)acids)to) the)portal)system)due)to:)) •  increased)rate)of) lipolysis) ) )in)visceral)fat)cells) •  )Elevated) Portal free fatty acids ) )has)a)number)of) )))) undesirable)effects)including:))) •  Glucose)intolerance) •  Dyslipidemia)) •  Hyperinsulinemia) (likely)the)result)of)abnormal)hormo...
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