BIOL
BIOL 2050 Lecture 10 DNA translation

BIOL 2050 Lecture 10 DNA translation - DNA transcription...

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10/16/2011 1 DNA transcription BIOL2050 Lecture 10 RNA structure and function Components needed for transcription Transcription mechanism Differences between Eukaryote and Prokaryote transcription Enzymes involved in transcription Overview Central dogma of Molecular Biology 1. DNA replicates: replication 2. DNA codes for messenger RNA (mRNA): t ranscription 3. Eukaryotic cells mRNA migrates to cytoplasm after processing 4. mRNA carries coded information to the ribosomes, ribosomes read this and produce proteins: translation
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10/16/2011 2 Transcription and translation Transcription and translation Replication Cell division Transcription is... The synthesis of RNA from a DNA template DNA sequence has information specifying all genes organism can make BUT this information in DNA is static or encrypted Intermediate molecule , a copy of the discrete gene, needed, using DNA as template This molecule is RNA , and it is synthesised by transcription Why is transcription important?
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10/16/2011 3 RNA structure Polynucleotide strand joined by phosphodiester bonds Phosphate sugar (ribose) backbone Four base pairs: A, G, C and U (uracil) RNA structure Usually single stranded But Folding may occur and hydrogen bonds form between bases form secondary structure Messenger RNA (mRNA) - Intermediate for translation to proteins, non functioning Functional RNA - Never translated to proteins - tRNA brings correct amino acid to mRNA - rRNA (ribosomal) guide assembly of amino acid chain in ribosome Types of RNA
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