BIOL 2050 Lecture 11 DNA translation

BIOL 2050 Lecture 11 DNA translation - DNA translation...

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10/30/2011 1 DNA translation BIOL2050 Lecture 11 Protein structure and function Characteristics of the genetic code Protein synthesis translation Translation in eukaryotes and prokaryotes Overview Central dogma of Molecular Biology 1. DNA replicates: replication 2. DNA codes for messenger RNA (mRNA): t ranscription 3. Eukaryotic cells mRNA migrates to cytoplasm after processing 4. mRNA carries coded information to the ribosomes, ribosomes read this and produce proteins: translation
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10/30/2011 2 Translation is... Assembling of amino acids into a protein on the ribosomes of the cell It is the final step in the production of proteins from DNA Proteins are central to all living processes Why is translation important? Enzymes Defence Scaffolding
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10/30/2011 3 Protein structure Chain of amino acids polypeptide chain 20 amino acids Each has a different R group Protein structure Chain of amino acids polypeptide chain Polypeptides have polarity Amino acids joined by peptide bonds Protein structure Several levels of protein structure Primary structure Polypeptide chain
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10/30/2011 4 Protein structure Several levels of protein structure Primary structure Polypeptide chain Protein structure Several levels of protein structure Secondary structure Shape given to polypeptide by folding Bonding forces between amino acids close together -Hydrogen bonds, van der Waals forces Most common are α helix and pleated sheet Protein structure Tertiary structure Folding of secondary structure
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