IMM334 TT2 2013 v1 Draft March 6

IMM334 TT2 2013 v1 Draft March 6 - UNIVERSITY OF TORONTO...

Info icon This preview shows pages 1–4. Sign up to view the full content.

UNIVERSITY OF TORONTO Faculty of Arts and Science Term Test II (v. 1) - 2012-13 IMM334Y1 Wednesday, March 6, 2013 Duration - 2 hours No aids allowed. Please use pencil. After completing this exam, you may NOT take the exam paper with you. This test consists of a total of 40 multiple choice questions (worth 1 mark each) Part A: Questions # 1 to 20; Type I - One Best Answer Part B: Questions # 21 to 40; Type II - Multiple Answer Type: Answer key provided on the appropriate pages BE SURE TO COMPLETE YOUR NAME AND STUDENT NUMBER ON THE SCANTRON SHEET
Image of page 1

Info icon This preview has intentionally blurred sections. Sign up to view the full version.

______________________________________________________________________________ Part A: Multiple Choice Questions #1 to 20 TYPE I: Choose the one best or most appropriate answer. ______________________________________________________________________________ 2/14 M. Julius 1. An immunoglobulin allotype congenic strain is prepared in which Ig b derived from C57BL/6 (Ig b , H-2 b ) is backcrossed onto a BALB/c (Ig a , H-2 d ) background. After the second backcross the proportion of pups expressing Ig a is A. 100% B. 50% C. 0% D. 0.1% E. 99.9% Ans. A 2. In question #1, the proportion of pups expressing Ig b is 3. In question #1, after the 10 th backcross, the proportion of pups expressing H-2 b is 4. An H-2 d/b , Ig a /Ig b F 1 mouse that has been thymectomized and lethally irradiated is reconstituted with bone marrow cells obtained from an H-2 b , Ig b mouse. In this animal you will observe
Image of page 2
______________________________________________________________________________ Part A: Multiple Choice Questions #1 to 20 TYPE I: Choose the one best or most appropriate answer. ______________________________________________________________________________ 3/14 Ans. D 5. You have prepared a [C57Bl/6 (Ig b , H-2 b )] [C3H (Ig a , H-2 k ) x C57Bl/6 (Ig b , H-2 b )] F 1 chimera that you immunize with KLH. Assume that the MHC is comprised of four genetic loci (K, I-A, I-E, and D). A CD4 + KLH-specific effector T cell in this chimera could be restricted by A. 1 of 8 MHC molecules B. 1 of 4 MHC molecules C. 1 of 2 MHC molecules D. 1 of 4 MHC class II molecules E. None of the above Ans. E 6. If the chimera in question #5 had been immunized with H-2 k/b APC expressing peptides derived from KLH, a CD4 + KLH specific effector T cell in this chimera could be restricted by
Image of page 3

Info icon This preview has intentionally blurred sections. Sign up to view the full version.

Image of page 4
This is the end of the preview. Sign up to access the rest of the document.
  • Fall '08
  • ABOUHAIDER
  • Major histocompatibility complex

{[ snackBarMessage ]}

What students are saying

  • Left Quote Icon

    As a current student on this bumpy collegiate pathway, I stumbled upon Course Hero, where I can find study resources for nearly all my courses, get online help from tutors 24/7, and even share my old projects, papers, and lecture notes with other students.

    Student Picture

    Kiran Temple University Fox School of Business ‘17, Course Hero Intern

  • Left Quote Icon

    I cannot even describe how much Course Hero helped me this summer. It’s truly become something I can always rely on and help me. In the end, I was not only able to survive summer classes, but I was able to thrive thanks to Course Hero.

    Student Picture

    Dana University of Pennsylvania ‘17, Course Hero Intern

  • Left Quote Icon

    The ability to access any university’s resources through Course Hero proved invaluable in my case. I was behind on Tulane coursework and actually used UCLA’s materials to help me move forward and get everything together on time.

    Student Picture

    Jill Tulane University ‘16, Course Hero Intern