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Williams BCH 444 2014 Lectures 3-6

Williams BCH 444 2014 Lectures 3-6 - BCH 444 Spring 2014...

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• Targeting nascent proteins to the endoplasmic reticulum • Protein translocation into the ER, membrane protein topology • Protein glycosylation, functions of glycoproteins • Protein folding in the ER, role of chaperones and folding catalysts • Protein quality control - ERAD and the UPR David B. Williams, Room 5316 MSB [email protected] BCH 444 Spring 2014 1
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2 Endoplasmic Reticulum (ER) - first stage in the secretory pathway - About 30% of cellular proteins are synthesized on membrane-bound ribosomes of the ER and are translocated partially (membrane proteins) or completely (soluble proteins) across the ER membrane. - This segregates them from other cellular proteins and establishes their topology as transmembrane or soluble proteins - These proteins are subsequently sorted to their final destinations as they move along the secretory pathway from ER to Golgi to cell surface
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