IMM334 TT2 March 6 2014 - UNIVERSITY OF TORONTO Faculty of...

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UNIVERSITY OF TORONTO Faculty of Arts and Science Term Test II - 2013-14 IMM334Y1 Thursday, March 6, 2014 Duration - 2 hours No aids allowed. Please use pencil. After completing this exam, you may NOT take the exam paper with you. This test consists of a total of 40 multiple choice questions (worth 1 mark each) Part A: Questions # 1 to 20; Type I - One Best Answer Part B: Questions # 21 to 40; Type II - Multiple Answer Type: Answer key provided on the appropriate pages BE SURE TO COMPLETE YOUR NAME AND STUDENT NUMBER ON THE SCANTRON SHEET
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______________________________________________________________________________ Part A: Multiple Choice Questions #1 to 20 TYPE I: Choose the one best or most appropriate answer. ______________________________________________________________________________ 2/15 M. Julius 1. A BAB10 mouse (Ig b , H-2 d ) is crossed with a C57BL/6 (Ig b , H-2 b ). Assume that the MHC is comprised of four genetic loci: K, I-A, I-E, and D. A CD4 + T cell in an F 1 pup could be restricted by: A. 1 of 8 MHC molecules B. 1 of 2 MHC molecules C. 1 of 6 MHC molecules D. 1 of 4 MHC molecules E. None of the above Ans. E 2. In the above question #1, a B cell in the F 1 pup: 3. You are preparing an Ig allotype congenic strain in which Ig a derived from Balb/c (Ig a , H-2 d ) is backcrossed onto a C57Bl/6 (Ig b , H-2 b ) background. After the 2 nd backcross: 4. In the above question #3, after the 10 th backcross:
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______________________________________________________________________________ Part A: Multiple Choice Questions #1 to 20 TYPE I: Choose the one best or most appropriate answer. ______________________________________________________________________________ 3/15 5. Ig allotype-specific antibodies: A. Can distinguish BALB/c IgG 1 from C57BL/6 IgG 1 B. Recognize peptide sequences that differ between IgA and IgG in the BALB/c C. Can distinguish IgM a from IgM b D. Can distinguish IgG 2a a from IgG 2b a E. All of the above Ans. E 6. One virus specific CD8 + effector T cell derived from an H-2 d H-2 d/b chimera immunized with virus could be restricted by: [Assume that MHC is comprised of four loci: K, I-A, I-E, D]
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  • Fall '08
  • ABOUHAIDER
  • T Cell, Major histocompatibility complex, T helper cell

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