Parvovirus_MGY378_2014 - DNA Viruses Papilloma Polyoma RNA...

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DNA Viruses RNA pol in virion Virion diameter (nm) Genome size (kb) Pa pilloma Po lyoma
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Parvoviruses 2 subfamilies – 1 that infects vertebrates - 1 that infects insects Vertebrate Viruses: 1) Parvovirus – many vertebrate viruses (nonhuman) 2) Amdovirus – Aleutian mink disease virus –related virus discovered recently in grey foxes 3) Erythrovirus – 3 human viruses (B19, PARV4, PARV5) - additional mammalian viruses 4) Bocavirus – 4 human viruses (common); 4 other mammalian viruses - Human bocavirus first discovered in 2005 - HBoV1 found in respiratory tract; associated with respiratory disease -HBoV2,3,4 found in stool 5) Dependovirus – Adeno-associated virus (AAV) - several kinds that infect humans and other vertebrates - requires co-infection with an unrelated helpervirus for productive infection (adenovirus or herpesvirus) Autonomous Parvoviruses
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B19 Common human virus Most people infected at some point Infects red blood cell precursors resulting in decreased production of red blood cells (a serious problem in hemolytic anemia patients where red blood cell levels are already low) Flu-like symptoms or no symptoms Can develop into Fifth Disease B19 commonly found in the heart; maybe site of lifelong persistence Can induce fetal death or complications when pregnant women are infected. 30% of pregnant women with B19 infection transmit it to the fetus. 5-10% of infected fetuses die due to anaemia and heart problems (those with underlie conditions). Most of the time mother and fetus are asymptomatic.
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Fifth Disease - build up of immune complexes - results in rash in children on cheeks and torso giving “slapped cheek” presentation
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  • Spring '14
  • DNA, virions

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