Volchuk BCH444 Jan. 7. 2014 Lecture #1(1)

Volchuk BCH444 Jan. 7. 2014 Lecture #1(1) -...

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1/7/2014 1 BCH444H   Spring   2014 Protein Trafficking in the Secretory & Protein   Trafficking   in   the   Secretory   & Endocytic   Pathways Course   Coordinator: Dr.   David   Williams Dept.   of   Biochemistry Room   5316,   Medical   Sciences   Bldg. [email protected] (416)   978 2546
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1/7/2014 2 BCH444   Course   Outline   (2014) Jan.   7 A.   Volchuk Introduction   to   secretory   pathway Jan.   9 A.   Volchuk ER   structure/function;   Phospholipid   biosynthesis Jan.   14 D.   Williams Targeting   proteins   to   ER,   Signal   sequence   and   SRP Jan.   21 D.   Williams Membrane   protein   topology,   protein   N glycosylation Jan.   16 D.   Williams Protein   translocation   into   the   ER Feb.   13 A.   Volchuk Introduction   to   vesicle   transport Jan.   28 D.   Williams Protein   folding   in   the   ER folding   catalysts Feb.   4 Quality   control   – ER   degradation   (ERAD) D.   Williams Jan.   23 D.   Williams Glycoprotein   functions Jan.   30 D.   Williams Protein   folding   in   the   ER chaperones Feb.   6 Quality   control   – the   Unfolded   Protein   Response D.   Williams Feb.   11             Mid Term   Exam:   no   class   that   day             6:00 7:30   pm   in   MSB   2172 Feb.   18,   20               Reading   week,   no   classes Feb.   25 ER Golgi   transport   – COPII   vesicles A.   Volchuk Feb.   27 ER Golgi   transport   – retrograde   transport A.   Volchuk Mar.   4 Intra Golgi   transport A.   Volchuk Mar.   6 Sorting   at   the   trans   Golgi   Network A.   Volchuk Mar.   11 Endocytosis endosome   formation D.   Rotin Mar.   13 Endocytosis endocytic   pathways D.   Rotin Mar 19 Polarized delivery of proteins D Rotin Final   Exam                 during   exam   period   in   Apr Mar.   19 Polarized   delivery   of   proteins D.   Rotin Mar.   21 Polarized   delivery   of   proteins D.   Rotin Vesicular   trafficking  ‐ SNARE   hypothesis W.   Trimble Mar.   25 Vesicular   trafficking  ‐ regulated   secretion W.   Trimble Mar.   27 Vesicular   trafficking  ‐ regulatory   proteins   I W.   Trimble Apr.   1 W.   Trimble Apr.   3 Vesicular   trafficking  ‐ regulatory   proteins   II
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1/7/2014 3 Mid term   exam: (25%) short   answer   format BCH444   Evaluation   Scheme   2014 Feb.   11 th 6:00   pm 7:30   pm   Location:    MSB   2172 Final   exam:   (50%)   short   answer   format;     3   hours Written   assignment: (25%) Written   critique   of   a   randomly   assigned   research   paper:   2   pages   (max) summarize   basic   research   question(s)   addressed,   experimental   approaches   used   and   main   results   obtained;   identify   some   potential   pitfalls   of   the   paper   and   suggest   potential   follow up   questions   and   experiments more   details
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