Exam 1 key - BSCI 110A/Broadie Midterm Exam #1 February 6,...

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Unformatted text preview: BSCI 110A/Broadie Midterm Exam #1 February 6, 2004 Name: K E z $I#: Read all instructions carefulM 1. . Do NOT open the exam until you are told to do so. 2. Write your name and student identification number on every mg; in the space provided. Check that there are (4 test pages + cover). 3. Nothing but your writing tools and test are permitted to be out in open view. No notes or books. 4. Answer all questions as succinctly and clearly as possible. Answers must be written or drawn in the sgce provided. Do not expand answers on the back of pages. Such extensions will not be graded. 5. You will have 50 minutes to complete the exam. This should be ample time. However, do not get stalled on any one question! Multiple Choice (50 pts) Match Lists (30 pts) Short Answer (20 pts) ————_— —-__—_ —-—-———-—_—_ E.— Total (100 pts) BSCI 110A/Broadie MidTerm Exam #1 February 6, 2004 Name: KE Z 51'#: MulTiple Choice: There is a single besT answer for each quesTion. Place The leTTer in The space provided. Each correcT answer is worTh 2 st. 50 st ToTal. c SmallesT Thing you can see wiTh an elecTron microscope in a cell is approx: A. 1 angsTr-om B. 1 micron C. 1 nanomeTer D. 1 micromeTer C The firsT cells evolved on EarTh approximaTely when (billions of years ago): A. 10.5 bya B. 7.5 bya C. 3.5 bya D. less Than 1 bya 8 The number of elecTrons in The M ouTer shell of Carbon is: A.12 3.8 C.6 D.4 A The approximaTe amounT of energy required To cleave a C—C bond: A. 85 kcal/mol B. 25 kcal/mol C. 10 kcal/mol D. 1 kcai/mol C A fully saTuraTed hydrocarbon is: A. polarized B. ionized C. hydrophobic D. hydrophilic The following besT defines The chemical composiTion of sugar: A. (CH-£0)n B. (Cl-i4)n C. (Cl-MO)n D. (CZHEO)n 8 The region of an amino acid ThaT carries aflfl posiTive charge in waTer: A. carboxyl group 8. amino group C. on carbon D. pepTide bond The amino acid side chain —CH2—OH falls inTo The following class: A. polar B. non—polar C. acidic D. basic 8 In an a—heiix, The number of amino acids per Turn (aISO beTween H—bonds): A.2 B4 C6 D.8 [a A reacTion is described as Thermodynamically unfavorable if: A. A6 = 0 B. AG is negaTive C. AG is posiTive D. AG > -1 8 If The equiiibrium consTanT (Keg) for a reacTion is greaTer Than 1, Then: A. A6 = O 8. AG is negaTive C. A6 is posiTive D. AG > +1 R The following is parTicularly enriched in membrane lipid rafTs: A. cholesTerol B. phospholipids C. polysaccharides D. Triglycerides 2 BSCI 110A/Broadie Midterm Exam #1 February 6, 2004 Name: K E z SI#: 8 A protein enzyme does the following: A. provides energy for unfavorable rxns B. decreases activation energy C. makes AG more negative D. changes rxn equilibrium D Within a membrane, a phospholipid can exchange the following: A. fatty acids B. into H20 C. between bilayer leaflet D. rotation position A The following would separate an integral membrane protein from membrane: A. detergent B. high pH C. low pH D. high salt concentration A protein forming 1 subunit of a channel would be predicted to contain: A. [3-barrel B. parallel B—sheet C. amphipathic a-helix D. hydrophobic a—helix D A trait distinguishing a transmembrane carrier from a channel: A. its a transmembrane protein B. always requires energy input to work C. tight cargo specificity D. can transport up a concentration gradient (1 How many covalent bonds are cleaved in 1 complete cycle of the Na/ K pump: AU 3.1 6.2 DB 3 If [Na+] increased outside an intestinal cell, then glucose transport would: A. stop B. increased rate C. decreased rate D. no change A The primary channels determining a cell's resting membrane potential are: A. K+ leak B. Na+ leak C. voltage-gated K+ D. voltage-gated Na+ D The class of channel required to receive a synaptic signal: A. K+ leak B. voltage—gated C. mechanically gated D. ligand—gated C The Freeze Slammer machine was used to: A. measure rate of action potential B. assay voltage-gated ion channels C. arrest synaptic transmission D. test membrane kinetics 8 Approximately how long does it take for the plasma membrane to recycle: A. 1 day B. 1 hour C. 10 minutes D. 1 minute 8 A protein with a parallel [ii-sheet at the N terminus would be trafficked to: A. plasma membrane B. cytosol C. endoplasmic reticulum D. golgi C I The most common protein glycosylation involves oligosaccharide addition: A. in the cyTOSol B. outside the cell C. to asparogines D. to serines 3 BSCI 110A/Broadie Midterm Exam #1 February 6, 2004 Name: KEX , SI#: List matching: There is a single best order for each question. Place the numbers (1 to 5) in the space provided. Each question is worth 5 points. 30 points total. —_——_—__—__ Rank in order of size: 1 (smallest) to 5 (largest) Lphospholipidlaverage proteinivirus S mitochondrion 3 ribosome Rank in order of abundance in cells: 1 (most abundant) to 5 (least abundant) .1 oxygen __2__carbon _"_l'_ nitrogen _L hydrogen ___S:sulfur L. a“) .1 Rank in order of abundance in cells: 1 (most abundant) to 5 (least abundant) _l__H20 §__ salts _€l—_ polysaccharides i lipids (all) _g_ polypeptides Rank in order of strength: 1 (strongest) to 5 (weakest) _2.._ ionic bond (in a hydrophobic environment) 3 ionic bond (in H20 environment) _J_ covalent band i hydrogen bond _s: van—dz" Waals bond Rank in order of molecular abundance (# of molecules) in typical animal cell membrane: 1 (most abundant) to 5 (least abundant) Asphingolipid Lphospholipids _'2—_cholesterol _‘-l'_ protein i polysaccharide Rank in order of occurrence during an action potential in a nerve cell: 1 (earliest) to 5 (latest) S hyperpolarization l depolarization 3 inactivation of Na+ channels i opening of K+ channels 7- opening of Na+ channels BSCI 110A/Broadie MidTerm Exam #1 February 6, 2004 Name: K32 ‘ SI#: Sher-T answer: USe only space provides. Any exTensions (on back or elsewhere) will noT be graded . Each quesTions is worTh 5 poinTs. 20 poinTs ToTal. Draw a carToon of a phosphofipid.‘ 1) place/name The 4 major Types of chemical groups (box wiTh name inside), 2) indicaTe hydrophilic/ hydrophobic regions. (- Polw haul [a Mo IA.ch Gym-a K‘le‘PN‘ ] 3 P _ '* fl WW Draw a carToon of ATP: 1) place/name The major chemical groups (box wiTh name inside), 2) indicaTe The bond(s) linking groups whose cleavage liberaTes ~26 kcal/mol. 0 99 M Mme. 9% load; Ml £09. C(MLJ (ATP—314MB) Draw a diagram of free energy (Y axis) vs. rxn paTh (X axis) showing energy sTaTes of reacTanT producTs in 1) an unfavor le rxn and 2) wiTh/wiThouT an enzyme. rxn pd'k -—-’7 _ . _ . Draw a ploT of membrane TransporT raTe (Y axus) vs. concenTra‘hon (X axus) showmg 1) curves comparing diffusion and faciiiTaTed Tran5porT, 2) Vmax/KM for The laTTer. fie owl-inn Pdl‘fi CSulewlCl ...
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