Review - 1 Today Population Genetics Recap Guest Lecture...

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Today: Population Genetics Recap Guest Lecture Monday Nicole Office Hours: Tuesday: 12:30-2:30 Midterm Wednesday 1
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HWE is a mathematical model that allows us to calculate expected allele and genotype frequencies for populations that are NOT evolving at a particular locus. (Ie. It is a null model of evolution) Predictions of the null model: 1.Allele frequencies are constant. 2.Genotype frequencies are constant. 3.One generation of random mating will return a population to equilibrium frequencies. 2
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A a Single locus model Simplest case No selection No mutation No drift No migration Random mating --------------> HW Eqm 3
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HWE – How To: Genotypes A 1 A 1 A 1 A 2 A 2 A 2 Observed 175 50 10 4 The answers are posted on the following slides. Make sure to work through the answer on your own before advancing slides!
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HWE – How To: Genotypes A 1 A 1 A 1 A 2 A 2 A 2 Observed 175 50 10 235 Use allele frequencies and HWE equation to calculate expected genotype frequencies 0.72 0.26 0.02 1 Expected Frequencies 5
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HWE – How To: Genotypes A 1 A 1
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