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2 33 histone deacetylation transcriptional repression

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Unformatted text preview: excluded • Nucleosomal DNA ---> all Nucleosomal factors bind factors • HR may bind on nucleosome HR surface and make alterations that allow binding of other factors to build transcription activation complex activation Lewin Genes VII 2000 Oxford University Press 32 HISTONE DEACETYLATION & TRANSCRIPTIONAL REPRESSION • • • Lysine on histone tails are targets of acetylation by histone acetyltransferases (HATs) Histone acetylation “loosens” bound DNA in nucleosomes ---> gene activation Histone deacetylase “tightens” DNA binding in nucleosomes ---> gene repression Weaver 2002 Molecular Biology Ed. 2 33 HISTONE DEACETYLATION & TRANSCRIPTIONAL REPRESSION • • a variety of co-activators of transcription have histone acetyltransferase (HAT) activity-may loosen association of nucleosomes with gene control region known repressors of transcription can interact with co-repressors wich interact with histone deactylases to tighten grip of histones on DNA Weaver 2002 Molecular Biology Ed. 2 eg. in absen...
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