{[ promptMessage ]}

Bookmark it

{[ promptMessage ]}

MBB331_Week10-Fall-2011

Factor families transcription homeodomainmotifs helix

Info icon This preview shows page 1. Sign up to view the full content.

View Full Document Right Arrow Icon
This is the end of the preview. Sign up to access the rest of the document.

Unformatted text preview: homeodomain of Drosophila Drosophila Engrailed bound to DNA determined determined Lewin Genes VII 2000 Oxford University Press 7 TRANSCRIPTION FACTOR FAMILIES: TRANSCRIPTION HOMEODOMAIN MOTIFS • Helix-3 lies in major groove and Helix-3 makes majority of contacts with DNA, helix-1 projects into minor groove and makes other contacts with DNA contacts Lewin Genes VII 2000 Oxford University Press 8 TRANSCRIPTION FACTOR FAMILIES: HELIX­LOOP­ HELIX­ HELIX (HLH) MOTIFS • • • • • Helix-loop-helix motif: 40-50 amino acids - 2 amphipathic α helices separated by loop HLH amphipathic helices: one HLH helix face hydrophobic, other face charged & hydrophilic HLH proteins form both HLH homodimers and heterodimers through interactions between hydrophobic amino acids in helices helices bHLH proteins have highly basic HLH DNA binding region adjacent to HLH motif HLH a homodimer or heterodimer in homodimer which both subunits contain basic both region can bind DNA like a pair of tongs tongs Weaver 2002 Molecular Biology Ed. 2 9 TRANSCRIPTION FACTOR FAMILIES: HELIX­LOOP­HELIX (HLH) M...
View Full Document

{[ snackBarMessage ]}

What students are saying

  • Left Quote Icon

    As a current student on this bumpy collegiate pathway, I stumbled upon Course Hero, where I can find study resources for nearly all my courses, get online help from tutors 24/7, and even share my old projects, papers, and lecture notes with other students.

    Student Picture

    Kiran Temple University Fox School of Business ‘17, Course Hero Intern

  • Left Quote Icon

    I cannot even describe how much Course Hero helped me this summer. It’s truly become something I can always rely on and help me. In the end, I was not only able to survive summer classes, but I was able to thrive thanks to Course Hero.

    Student Picture

    Dana University of Pennsylvania ‘17, Course Hero Intern

  • Left Quote Icon

    The ability to access any university’s resources through Course Hero proved invaluable in my case. I was behind on Tulane coursework and actually used UCLA’s materials to help me move forward and get everything together on time.

    Student Picture

    Jill Tulane University ‘16, Course Hero Intern