MBB331_Week10-Fall-2011

Intron 5 or 6 are the first removed then the other is

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Unformatted text preview: ind each other & join? other correct pairwise correct combinations are not based on additional sequence information and 5´and 3´splice sites are interchangeable interchangeable eg. hybrid RNA precursors constructed cursors where 1st exon of SV40 early transcript spliced to 3rd exon of β -globin… no -globin… sequence important other than splice donor & acceptor sites acceptor Lewin Genes VII 2000 Oxford University Press 68 • • • HOW ARE EXONS CORRECTLY HOW ARE EXONS CORRECTLY JOINED? Splice sites are generic & Splice ubiquitous - RNA spliced in any cell in despite the fact that splice despite sites are generic, recognition of the sites is set up so that only the 2 sites of the same intron are spliced together are there appear to be there preferred pathways of splicing, which may mean that conformation of the RNA at a given time allows accessibility of certain splice sites splice Lewin Genes VII 2000 Oxford University Press 69 INTRONS REMOVED IN SPECIFIC ORDER INTRONS REMOVED IN SPECIFIC ORDER • RNA precursors to ovomucoid RNA mRNA: discrete & simple set o...
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