MBB331_Week10-Fall-2011

Of target genes when emc protein is available it

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Unformatted text preview: dopt sensory organ fate -AC-S and da are genes of the bHLH type, while the suppressor codes for an HLH protein that lacks the basic region -in the absence of emc function, da and AC-S proteins form dimers that activate transcription of target genes; when emc protein is available it forms heterodimers with da and AC-S that can’t bind DNA 13 Lewin Genes VII 2000 Oxford University Press TRANSCRIPTION FACTOR FAMILIES: LEUCINE ZIPPER MOTIFS LEUCINE ZIPPER MOTIFS • • • • DNA binding protein dimerization DNA often important- as we have seen in bacteria, phage, eukaryotes bacteria, leucine zipper proteins well studied leucine example of how dimer formation positions DNA-binding regions of ecah subunit ecah each subunit contains half the each “zipper”: an α -helix with leucines -helix spaced 7 amino acids apart such that they all protrude from one face of helix of the zipper is a coiled coil formed the when leucines of two subunits interdigitate interdigitate Weaver 2002 Molecular Biology Ed. 2 14 TRANSCRIPTION FACTOR FAMILIES: LEUCINE ZIPPER MOTIFS LEUCINE ZIPPER MOTIFS • • • • adjacent to leucine dimerization adjacent zipper, DNA binding basic region basic formation of the zipper by 2 formation proteins forms a tong-like structure called bZIP which “grasps” DNA bZIP target sequences which are inverted repeats w...
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