Of target genes when emc protein is available it

Info iconThis preview shows page 1. Sign up to view the full content.

View Full Document Right Arrow Icon
This is the end of the preview. Sign up to access the rest of the document.

Unformatted text preview: dopt sensory organ fate -AC-S and da are genes of the bHLH type, while the suppressor codes for an HLH protein that lacks the basic region -in the absence of emc function, da and AC-S proteins form dimers that activate transcription of target genes; when emc protein is available it forms heterodimers with da and AC-S that can’t bind DNA 13 Lewin Genes VII 2000 Oxford University Press TRANSCRIPTION FACTOR FAMILIES: LEUCINE ZIPPER MOTIFS LEUCINE ZIPPER MOTIFS • • • • DNA binding protein dimerization DNA often important- as we have seen in bacteria, phage, eukaryotes bacteria, leucine zipper proteins well studied leucine example of how dimer formation positions DNA-binding regions of ecah subunit ecah each subunit contains half the each “zipper”: an α -helix with leucines -helix spaced 7 amino acids apart such that they all protrude from one face of helix of the zipper is a coiled coil formed the when leucines of two subunits interdigitate interdigitate Weaver 2002 Molecular Biology Ed. 2 14 TRANSCRIPTION FACTOR FAMILIES: LEUCINE ZIPPER MOTIFS LEUCINE ZIPPER MOTIFS • • • • adjacent to leucine dimerization adjacent zipper, DNA binding basic region basic formation of the zipper by 2 formation proteins forms a tong-like structure called bZIP which “grasps” DNA bZIP target sequences which are inverted repeats w...
View Full Document

{[ snackBarMessage ]}

Ask a homework question - tutors are online