Chapter 23 Notes: drugs for hypertension

Chapter 23 Notes: drugs for hypertension - Chapter 23...

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Chapter 23 Drugs for Hypertension (HTN) Normal: SBP < 120 and DBP < 80 Prehypertension: SBP 120-139 or DBP 80- 89 Stage 1 hypertension: SBP 140-159 or DBP 90-99 Stage 2 hypertension: SBP >160 or DBP 100 or more Hypertension (HTN) A prolonged elevation in blood pressure Risk factors: Age Race Family history Overweight or obese Physically inactive Smoking Factors Responsible for Blood Pressure Systole (work) Diastole (rest) Pulse pressure Cardiac output Stroke volume Peripheral vascular resistance (PVR) Afterload Preload Blood Vessels Blood vessels: Arteries Veins Arterioles Capillaries Tunica intima Tunica media Tunica adventitia Physiologic Regulation of BP Vasomotor center Baroreceptors
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Chemoreceptors Antidiuretic hormone (ADH): vasoconstrictor Renin-angiotensin-aldosterone system The Selection of Drugs for HTN Goals is to reduce the morbidity and mortality associated with chronic HTN
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Unformatted text preview: • patient responses vary widely • The following drugs are used: • diuretics • angiotensin-converting enzyme (ACE) inhibitors • angiotensin II receptor blockers (ARBs) • beta-blocking agents • calcium channel blockers • In combination: antihypertensive with thiazide diuretic Diuretics • First-line drugs for HTN • Fewer side effects • Very effective at controlling BP • Can be used alone or in combination with other • antihypertensives • All reduce blood volume through urinary excretion of water and electrolytes Types of diuretics • Thiazide and thiazide-like • causes loss of potassium • hydrochlorothiazide (HCTZ) • Potassium-sparing • modest diuresis • do not cause potassium depletion • Loop diuretics • strongest diuretic, cause potassium depletion...
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  • Spring '13
  • Crawford
  • Diuretic, (HTN)

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