This preview shows page 1. Sign up to view the full content.
Unformatted text preview: -O O N O POPO P O- O- O- O 5 H GTP H O H
OH 3/ NH 2. Guanylyltransferase
N NH2 OH O H
OH O mRNA capping enzyme is a bifunctional
enzyme with RNA triphosphatase and
RNA guanylyltransferase activities on
separate domains. The guanylyltransferase domain binds to RNAP II phosphorylated CTD. O / O
H N P H N N H
OH / H
OH H O3 OO H N
NH2 -O O P O P OO- O O- N -O P O N O
H H OH H
OH N PO P O O- O
H –O N
H H O3 N H
OH / N P
OO 5 O O / H
H H O H
OH 3/ B. N N O
NH2 H O Phosphoanhydride linkage NH N O The capping enzyme is associated with which region of the RNA
polymerase II? RNAP II Rpb1 C-terminal domain CTD 13 Initials:___________________
34. 10 pts
A. With chemical structures, draw the chemical reaction for the incorporation of
the next nucleotide into the mRNA molecule below. Show the chemical
structure of the RNA product (only the terminal 2 nucleotides).
(Show the complete chemical structure of the incoming substrate that is used
for this reaction, but only the terminal nucleotide of th...
View Full Document
This test prep was uploaded on 03/23/2014 for the course CHEMISTRY 4141 taught by Professor Jonklaas during the Spring '13 term at Baylor.
- Spring '13