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Unformatted text preview: the following statements
about proteins that participate in mammalian DNA replication is NOT correct? a.
e. A designates one subunit of the ATP-dependent helicase, MCM
B designates DNA pol ε, a classical B family enzyme with proofreading
3/ –>5/ exonuclease activity
C designates RFC, replication factor C which is the ATP-dependent clamp loader
D designates DNA pol α
E designates RPA, replication protein A which binds to single stranded DNA and
prevents it from re-annealing 7. Which of the following statements about DNA replication in eukaryotes is NOT correct?
ORC, the origin recognition complex, binds to DNA with little specificity
actual initiation sites are determined by the pre-RC
although the pre-RC is huge, the actual RC consist of just a few proteins
formation of the pre-RC and its activation are two distinct events
replication on a segment of DNA occurs only once per cell cycle 2 8. E. coli DNA pol I:
e. hydrolyzes RNA primers on the lagging strand, and replaces them with DNA
catalyzes the following reaction:
5/-(dNMP)n-3/-OH + dNTP –> 5/-(dNMP)n-dNMP -3/-OH + PPi
has 5/ –> 3/exonuclease activity
has 3/ –> 5/exonuclease activity
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This test prep was uploaded on 03/23/2014 for the course CHEMISTRY 4141 taught by Professor Jonklaas during the Spring '13 term at Baylor.
- Spring '13