What kind of mutation is g197 a

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Unformatted text preview: PheAlaSerAspThrThrValPheThrSerAsnLeuLysGlnThrPro Frame-shift HisLeuLeuLeuThrGlnLeuCysSerLeuAlaThrSerAsnArgHisHisE. Major, non-frameshift, change in many amino acids ATGGTGCACCTGACTCCTGAGGAGAAGTCTGCCGTTACTGCCCTGTGGGG 151 ---------+---------+---------+---------+---------+200 TACCACGTGGACTGAGGACTCCTCTTCAGACGGCAATGACGGGACACCCC 0 10 METValHisLeuThrProGluGluLysSerALAValThrAlaLeuTrpGly - TrpCysThrEndLeuLeuArgArgSerLeuProLeuLeuProCysGlyAla GlyAlaProAspSerEndGlyGluValCysArgTyrCysProValGly - TGTAAACGAAGACTGTGTTGACACAAGTGATCGTTGGAGTTTGTCTGTGG IleCysPheEndHisAsnCysValHisEndGlnProGlnThrAspThr iClicker Question 5: ThrPheAlaSerAspThrThrValPheThrSerAsnLeuLysGlnThrPro HisLeuLeuLeuThrGlnLeuCysSerLeuAlaThrSerAsnArgHisHis- Another kind of beta- zero- thalassemia is caused by the mutation T245C. What kind of mutation is T245 C? ATGGTGCACCTGACTCCTGAGGAGAAGTCTGCCGTTACTGCCCTGTGGGG A. Silent 151 ---------+---------+---------+---------+---------+200 B. TACCACGTGGACTGAGGACTCCTCTTCAGACGGCAATGACGGGACACCCC Minor missense (~similar properties) 0 10 C. METValHisLeuThrProGluGluLysSerALAValThrAlaLeuTrpGly Major missense (very different properties) rpCysThrEndLeuLeuArgArgSerLeuProLeuLeuProCysGlyAlaD. TFrame-shift GlyAlaProAspSerEndGlyGluValCysArgTyrCysProValGly E. Major, non-frameshift, change in many amino acids CAAGGTGAACGTGGATGAAGTTGGTGGTGAGGCCCTGGGCAGGTTGGTAT 201 ---------+---------+---------+---------+---------+250 GTTCCACTTGCACCTACTTCAACCACCACTCCGGGACCCGTCCAACCATA 20 30 LysValAsnVALAspGluValGlyGlyGluAlaLeuGlyARGLeuValSerArgEndThrTrpMetLysLeuValValArgProTrpAlaGlyTrpTyr GlnGlyGluArgGlyEndSerTrpTrpEndGlyProGlyGlnValGlyIle -...
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This note was uploaded on 03/28/2014 for the course BIO 111 taught by Professor White during the Fall '11 term at University of Massachusetts Boston.

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