Practice MT

b now briefly explain the reasoning for your choice

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Unformatted text preview: the reasoning for your choice (a) in the space provided below. In your written explanation, do not refer to any of the structures you did not choose in (a). You must explain your choice (a) based solely on the merits of your choice alone. Use either “average molecule language” or “PMS language” in your explanation. 6 Question #5 (6 points) Consider the structure of the neutral, uncharged form of glutathione. Note this says pKb pKa ~ 2 O OH C pKb ~ 4 NH 2 C (CH2)2 H O H CN CCN H O CH2 SH O (CH2)2 C H OH pKa ~ 4 pKa ~ 8 Estimate the pHI of glutathione. Note: For partial credit, it is important to show your written work in a form the marker can understand. A verbal clarification of your method following exam grading will not be considered. 7 Question #6 (8 points) (a) You need to do something to help distinguish two possible protein structures. Indicate whether the indicated action would be useful to do by answering YES or NO. Example Problem Action Useful? You need to distinguish between Compare a fibrous protein and a globular protein the gross shape of the proteins YES Problem Action Useful? You need to distinguish between Compare (1) a fibrous protein and a globular protein the surface area/volume ratio of the two proteins ________ (2) a multi-domain monomeric protein and an oligomeric protein the results of completely denaturing each protein ________ (3) a monomeric globular protein and a subunit of a globular oligomeric protein the presence/absence of intrachain -S-S-bonds in each polypeptide ________ (4) a single domain monomeric lipid-soluble protein and a single domain monomeric water-soluble protein the amino acid composition of the two proteins ________ (b) Now briefly explain your reasoning for one of your choices in (1)-(4) The choice I am explaining is (1)...
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