201-13-5-Metabolism II-April 3 & 5-2 to post

To create a high energy phosphorylated intermediate

Info iconThis preview shows page 1. Sign up to view the full content.

View Full Document Right Arrow Icon
This is the end of the preview. Sign up to access the rest of the document.

Unformatted text preview: 6 steps) Oxida,ve conversion of glyceraldehyde 3- phosphate to pyruvate and the coupled forma,on of ATP and NADH Rx. 9 Rx. 10 Moran et al. Figure 10.2 Animal Metabolism (II)! Glucose Catabolism & Glycolysis! Reac,ons 6 & 7: Substrate level phosphoryla,on The glyceraldehyde- 3- phosphate dehydrogenase- phosphoglycerate kinase reac,ons Oxida,on- reduc,on rxn. to create a high- energy phosphorylated intermediate Phosphoryla,on of ADP The process of SLP always involves 2 reac,ons, each catalyzed by an enzyme. Animal Metabolism (II)! Glucose Catabolism & Glycolysis! Reac,on 6 & 7: Phosphoryla,on of ADP A phosphoryl group is transferred from 1,3- BPG (high- energy intermediate form Rxn. # 6) to ADP forming ATP. Rxn. # 6 Rxn. # 7 Animal Metabolism (II)! Fate of Pyruvate! Animal Metabolism (II)! Anaerobic Catabolism & Glycolysis! Reac,on 11: Oxida,on- Reduc,on Reac,on Oxidized NADH NAD+ Reduced Ketone- C Alcohol- C Under anaerobic condi,ons NADH produced in Rxn.#6 cannot be used to make ATP by Oxphos NADH is used to reduce Pyruvate to Lactate, so NAD+ is recycled / recovered to be used again. Animal Metabolism (II)! Anaerobic Catabolism & Glycolysis! Reac,on 11: Oxida,on- Reduc,on Reac,on Glucose 2 Glyceraldehyde-3-phosphate 2 NAD+ 2 NADH/H+ 2 Pyruvate 2 NADH/H+ lactate dehydrogenase 2 NAD+ Enzyme: Dehydrogenase 2 Lactate Purpose: To recycle NAD+ so it can be used again Animal Metabolism (II)! Aerobic versus Anaerobic Catabolism! Aerobic Condi,ons:...
View Full Document

This note was uploaded on 04/01/2014 for the course BIOL 201 taught by Professor Chowrira during the Winter '13 term at The University of British Columbia.

Ask a homework question - tutors are online