201-13-5-Metabolism II to post

Resonance ve charge spread out by electron

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Unformatted text preview: 3C + 3C Animal Metabolism (II)! Glucose Catabolism & Glycolysis! 6C, F 1,6- bisP split right in the middle the e- (from bond breaking) goes with the α carbon Carbanion (unstable intermediate) formed Stabiliza2on of the –ve charge (on carbanion) accomplished in 2 ways: 1. Resonance: - ve charge spread out by electron delocaliza2on involving the C = O group 2. +ve charged prosthe2c group (eg. Zn+2) helps to stabilize the –ve charge Animal Metabolism (II)! Glucose Catabolism & Glycolysis! Reac2on # 4: Sugar- spliYng Reac2on Enzyme: Synthase (Aldolase) Named for catalysis of the reac2on in the reverse direc2on! Now we see the purpose of Rxn. # 3….. By doubly phosphoryla2ng F 1,6- bisP, the cell ensures that both the 3C molecules are charged (when the 6C molecule is split) and both will stay in the cell once created! Also the purpose of the Rxn. # 2: The C = O group is moved (from C1 to C2) so that it is in the “right place” to facilitate resonance delocaliza2on of the –ve charge on the carbanion. Rx. 5 Rx. 6 Animal Metabolism (II)! Glucose Catabolism & Glycolysis! Reac2on # 5: DHAP isomerized to G- 3P Rx. 7 We now have 2 G- 3- P From this point on, all Rxns. x 2 Rx. 8 Rx. 9 Rx. 10 Enzyme: Isomerase → catalyzes the isomeriza2on of G- 3- P (aldose) and DHAP (ketose) Animal Metabolism (II)! Glucose Catabolism & Glycolysis! Reac2ons 6 & 7: Substrate level phosphoryla2on The glyceraldehyde- 3- phosphate dehydrogenase- phosphoglycerate kinase reac2ons Oxida2on- reduc2on rxn. to create a high- energy phosphorylated intermediate...
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This note was uploaded on 04/01/2014 for the course BIOL 201 taught by Professor Chowrira during the Winter '13 term at UBC.

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