Intermediate formed moreresonance contributors

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Unformatted text preview: -leavinggroup withcatalysis,wehaveROH Goodnucleophile,butbadleaving group,viceversa mostimportantstepis.. ionpair:stabilize hydrogenbondto certaindegree RNase: acid/base catalysis 3. Acid forms a better leaving group (ROH) Transition State #1 uncatalyzedsituation goodleaving group,process isnowfast badleaving group e- migration - Leaving group (hasn’t left yet) e- migration O ---------- P ----------- O-5’-Ribose Bond forming Bond breaking Development of negative charge RNase: acid/base catalysis 3. Acid forms a better leaving group (ROH) a) His-119 acts as a base/acid and donates a proton to the 5’-oxygen atom of the next nucleotide residue to produce an alcohol leaving group – Product 1 (P1). RNase: acid/base catalysis 4. Intermediate formed RNase: acid/base catalysis 4. Intermediate formed moreresonance contributors (chargeargument weaker) tetrahedral...
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This note was uploaded on 04/01/2014 for the course BIOL 201 taught by Professor Chowrira during the Winter '13 term at The University of British Columbia.

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