Substrate binding purinewouldnotfitinto thispocket

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Unformatted text preview:  cycle intermediateformed splitintotworxns (intermediateformation) 1)substratebinding 2,5 3,6samerxns symmetry: pingpong mechanism product#2released, enzymeregenerated,cycle complete baseformsnucleophile acidformsleavinggroup RNase: acid/base catalysis 1. Substrate binding purinewouldNOTfitinto thispocket cutonlyafterpyrimidine RNase: acid/base catalysis 2. Base forms a strong nucleophile (RO-) negativecharge RNase: acid/base catalysis 2. Base forms a strong nucleophile (RO-) nowacid! : RNase: acid/base catalysis 2. Base forms a strong nucleophile (RO-) : RNase: acid/base catalysis 2. Base forms a strong nucleophile (RO-) : removalofprotonbecausesoclosetogether,generates negative...
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This note was uploaded on 04/01/2014 for the course BIOL 201 taught by Professor Chowrira during the Winter '13 term at The University of British Columbia.

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