Ifmorestablethan productproduct wouldntform

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Unformatted text preview: geometry Compare: stability of the intermediate stability of the substrate/product stability of the transition states RNase: acid/base catalysis 4. Intermediate formed Why is the cyclic intermediate less thermodynamically stable than substrate/product? The geometry around the central P atom is tetrahedral (the same) in the substrate, products, and intermediate. However, in the cyclic intermediate, one of the O-atoms is also “pulled” to the 2’-C of ribose, putting strain on the P-O bond. fivememberedring charges?? Strained bonds = weaker bonds = contributes to lower intermediateishigherenergy thermodynamic stability. RNase: acid/base catalysis 4. Intermediate formed Why is the cyclic intermediate more thermodynamically stable than the transition states? The TS has five ligands => steric strain. The TS has more charged centres. The TS has charge separation. RNase: acid/base catalysis 4. Intermediate formed Intermediates, although less thermodynamically stable th...
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This note was uploaded on 04/01/2014 for the course BIOL 201 taught by Professor Chowrira during the Winter '13 term at The University of British Columbia.

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