2-ionization handout2

Case study 2 acetyl salicylic acid poisoning case

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Unformatted text preview: . Case Study #2 Acetyl Salicylic Acid Poisoning Case Study #2 Acetyl Salicylic Acid Poisoning OO C OCH H O C C3 3 OH COOH Pain killer pKa ~ 4 Overdose treated with i.v. NaHCO3 solution. Case Study #2 The Kidney Typical “normal” urine pH is ~6 - varies according to diet. inordertoreabsorb,mustcrossthecells.Wewantthemnotpermeable throughthemembrane Case Study #2 The Kidney Diffusion across a lipid bilayer is important for reabsorption of small molecules. Fluid motion of lipid bilayer opens gaps through which small molecules can move. Hydration of small molecules increases effective size of molecule. Ionized molecules order water to a greater degree and are effectively larger and therefore permeate lipid bilayers less readily. In case study #2, we want to promote excretion, not reabsorption. Increase ionization of molecule. Case Study #2 The Kidney OO C OCH H O C C3 3 OH COOH pKa ~ 4 PMS and AM of methyl salicylate before and after alkalinizat...
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