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does not compromise the respiratory status, so gas exchange is not impaired. 23 339. Anemia Sickle cell anemia is a group of diseases termed hemoglobinopathies, in which hemoglobin A is partly or completely
replaced by abnormal sickle hemoglobin S. It is caused by the inheritance of a gene for a structurally abnormal portion of the
hemoglobin chain. Hemoglobin S is sensitive to changes in the oxygen content of the red blood cell: Insufficient oxygen causes
the cells to assume a sickle shape, and the cells become rigid and clumped together, obstructing capillary blood flow. A
diagnosis is established on the basis of a complete blood count, examination for sickled red blood cells in the peripheral smear,
and hemoglobin electrophoresis. Laboratory studies will show decreased hemoglobin level and hematocrit and a decreased
platelet count, an increased reticulocyte count, and the presence of nucleated red blood cells. Reticulocyte counts are increased in
children with sickle cell disease because the life span of their sickled...
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This document was uploaded on 03/29/2014.
- Spring '14