Bioc 212 Lecture 5, 6 2014

36 nadhfadh to atp conversion 25 atp per nadh produced

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Unformatted text preview: glucose, total? – per palmitoyl (16 carbon side-chain fatty acid), under normoxic conditions? 36 NADH/FADH to ATP conversion? • 2.5 ATP per NADH produced in the matrix – costs energy to export that ATP • 1.5 ATP per NADH produced in the cytoplasm – costs energy to import & export • 1.5 ATP per FADH2 – FADH2 gives its electrons lower in the ETC, lower yield – TOTAL YIELD of ATP per glucose =30ATP 37 Table 14-1 Molecular Biology of the Cell (© Garland Science 2008) Figure 14-17 Molecular Biology of the Cell (© Garland Science 2008) !!!Also study the summary in Figure 14-8, below the figure... Figure 14-10 Molecular Biology of the Cell (© Garland Science 2008) Other functions for the Respiratory chain: Longevity and metabolism "For ----'s sake men—come on! Do you want to live forever?" - Sergeant Major Daniel Joseph "Dan" Daly (November 11, 1873 – April 27, 1937) 41 • The science of longevity CLK-1 is involved in biosynthesis of ubiquinone “Q” The National (US) institute of ageing 42 Thomas’ Research program: biological functions for RNAi in worms & human -endogenous RNAi -microRNA-mediated silencing Normal unc-22 (RNAi) -Fibronectin type III- C. elegans research led to ground-breaking discoveries including programmed cell death, development cell fate maps, metabolism regulation & ageing, numerous signaling cascades, neuron circuitry... & RNAi & microRNAs Revision/questions 44...
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