Bioc 212 Lecture 5, 6 2014

Starts by the coupling of two carbons carried by

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Unformatted text preview: by the coupling of two carbons carried by AcetylCoa, generating Citric acid (6 carbons) from Oxaloacetate (4 carbons). • Citric acid is progressively oxidized to yield high-energy activated carriers, and regenerate Oxaloacetate. • Each cycle produces 3 NADH, 1 FADH2, 1GTP, and 2 CO2 (waste). • Intermediates are used to generate a great diversity of biomolecules. • Requires Oxygen (aerobic), why? 3 Monday, 25 February, 13 Krebs cycle and B-oxidation takes place in the matrix of the mitochondria. the inner membrane caontain cistae, to increase SA. a lot of structure needed for mitochondria are coded by nuclear gene Figure 12-21 Molecular Biology of the Cell (© Garland Science 2008) mitochondria are organized along microtubules. Figure 14-5 Molecular Biology of the Cell (© Garland Science 2008) the layers of myofibrils are seperated by stacks of mitochondria because the heart needs a lot of O2 Figure 14-6 Molecular Biology of the Cell (© Garland Science 2008) Figure 14-7 (part 1 of 2) Molecular Biology of the Cell (© Garland Science 2008) Figure 14-7 (part 2 of 2) Molecular Biology of the Cell (© Garland Science 2008) Outer membrane: Porins let everything below 5kDa pass Inner membrane: impermeable, even to protons: rich in cardiolipins (specialized lipids) the intermembrane space is almost the same environment as the cytoplasm but the matrix is very different Figure 14-8 (part 1 of 2) Molecular Biology of the Cell (© Garland Science 2008) our job through the kreb cycle is to trap the energy from the e- into e- carriers we have a lot of NADH after the krebs cycle and a lot of O2 in the mitochondria, so what we need to do.... Figure 14-12a Molecular Biology of the Cell (© Garland Science 2008) .... harness the energy of the NADH high energy e- and let them relax pregressively through the ETC down to oxygen and we get as much energy as possible form the energy level. the enrgy of the e- are the same but the molecules that bind the e- can have certain configuration and they can handle these e- with lower and lower energy conformati...
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This note was uploaded on 04/01/2014 for the course BIOC 212 taught by Professor Dr.young during the Winter '11 term at McGill.

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