Bioc 212 Lecture 5, 6 2014

The chemistry of heme and cu allows o2 to capture on

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Unformatted text preview: nd of the ETC. the chemistry of heme and Cu allows O2 to capture on one hand. this is necessary to reduce O2 to H2O. Figure 14-28b Molecular Biology of the Cell (© Garland Science 2008) the chemistry between this Cu and heam group helps to clamp O2 and transfer that first e- Figure 14-27 Molecular Biology of the Cell (© Garland Science 2008) name the groups that bind at different energy levels the key steps Figure 14-29 Molecular Biology of the Cell (© Garland Science 2008) The electron transport, or respiratory chain • Composed of more than 15 electron carriers (>60proteins) embedded within the inner membrane • Sequential changes in conformation permit the translocation of protons across the membrane • Utilize Heme groups, Ubiquinone, Iron-Sulfur centres, and copper atoms to ‘handle’ the electrons. • The electrons move from one carrier to another, going from an high energy state, to the lowest energy state (towards greater redox potential) • The end point is the reduction of Oxygen into H20 26 there are 3 different conformations, 2 relaxation steps in this cycle only B to C is not spontaneously favored. C expresses its proton to the outside of mitochondria and now it has a low affinity for the proton so you have release of the proton to the IMS. The energy of this conformation is much higher than B so this has to be coupled. after giving up the proton it relaxes back to conf. A. faces inner complex of mitochondria and ahas high affinity for proton from B to C it is not spontaneouslt favored so it requires energy input and has to be coupled B shifts to C wiht a very strong input of energy conformation can be considered as shape of the complex. Figure 14-31 Molecular Biology of the Cell (© Garland Science 2008) spectroscopy can be used to look at the reduction state of these molecules. changes is spectroscopy can he used to show the flow of ewe can use inhibitors to block the change at different levels and then observe the spectroscopy. so that the chain upstream of the inhibitor is reduced and th...
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