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Unformatted text preview: nd of the ETC. the chemistry of heme and
Cu allows O2 to capture on one hand. this is
necessary to reduce O2 to H2O. Figure 14-28b Molecular Biology of the Cell (© Garland Science 2008) the chemistry between
this Cu and heam
first e- Figure 14-27 Molecular Biology of the Cell (© Garland Science 2008) name the groups that bind at different energy levels
the key steps Figure 14-29 Molecular Biology of the Cell (© Garland Science 2008) The electron transport, or
• Composed of more than 15 electron carriers
(>60proteins) embedded within the inner membrane
• Sequential changes in conformation permit the
translocation of protons across the membrane
• Utilize Heme groups, Ubiquinone, Iron-Sulfur centres,
and copper atoms to ‘handle’ the electrons.
• The electrons move from one carrier to another, going
from an high energy state, to the lowest energy state
(towards greater redox potential)
• The end point is the reduction of Oxygen into H20
26 there are 3 different conformations, 2 relaxation steps
in this cycle only B to C is not
spontaneously favored. C expresses its proton to the outside of
mitochondria and now it has a low affinity for the
proton so you have release of the proton to the
The energy of this conformation is much higher
than B so this has to be coupled.
after giving up the proton it relaxes back to conf. A. faces inner complex of mitochondria and ahas high affinity for proton from B to C it
spontaneouslt favored so it requires energy input
and has to be coupled B shifts to C wiht a very strong input of
energy conformation can be considered as shape of the complex. Figure 14-31 Molecular Biology of the Cell (© Garland Science 2008) spectroscopy can be used to look at the reduction state of these molecules.
changes is spectroscopy can he used to show the flow of ewe can use inhibitors to block the change at different levels and then observe the spectroscopy.
so that the chain upstream of the inhibitor is reduced and th...
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This note was uploaded on 04/01/2014 for the course BIOC 212 taught by Professor Dr.young during the Winter '11 term at McGill.
- Winter '11
- molecular biology