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Unformatted text preview: ations of Mc4r
have been found in severely obese humans20,21.
In addition to altering signaling through the pigmentation-associated Mc1r, agouti inhibits signaling through other melanocortin receptor subtypes as well (Table 1). Experiments with recombinant
protein and melanocortin receptors expressed in heterologous cells
have revealed that agouti, as expected, is a potent antagonist of
Mc1r. Agouti also inhibits signaling through Mc2r, which is exLa proteina Agouti si lega al
pressed in the adrenal gland, and Mc4r, which is expressed in the
recettore 1 della melanocortina
brain22. However, agouti has little effect on Mc3r, which is ex(Mc1r) hypothalamus, gut and placenta, or
pressed in the e blocca la trasduzione on Mc5r, which
is widely expressed. che porta alla sintesi
del segnale These biochemical data, along with the
physiological data observed with the targeted deletion of Mc4r in
d have eumelanina
mice, ella led to the current view that the ubiquitous expression of
agouti produces obesity by antagonizing signaling through Mc4r in
the brain. Agouti, however, does not normally...
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This document was uploaded on 04/02/2014.
- Fall '14