Unformatted text preview: dance or in
membranes. Determining the absolute
abundance of each protein, including all
modified forms, will be an important next
step. A complete interaction map of the proteins in a cell, and their cellular locations, will
serve as an atlas for the biological and medical explorations of cellular metabolism27
(see www.nrcam.uchc.edu, for example).
These and other related areas constitute the
developing field of proteomics.
NATURE | VOL 422 | 24 APRIL 2003 | www.nature.com/nature feature
Establishing a true understanding of how
organized molecular pathways and networks
give rise to normal and pathological cellular
and organismal phenotypes will require
more than large, experimentally derived data
sets. Once again, computational investigation will be essential (Box 3), and there will
be a greatly increased need for the collection,
storage and display of the data in robust
databases. By modelling specific pathways
and networks, predicting how they affect
phenotype, testing hypotheses derived from
these models and refining the models based
on new experimental d...
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