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A complete interaction map of the proteins in a cell

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Unformatted text preview: dance or in membranes. Determining the absolute abundance of each protein, including all modified forms, will be an important next step. A complete interaction map of the proteins in a cell, and their cellular locations, will serve as an atlas for the biological and medical explorations of cellular metabolism27 (see www.nrcam.uchc.edu, for example). These and other related areas constitute the developing field of proteomics. NATURE | VOL 422 | 24 APRIL 2003 | www.nature.com/nature feature Establishing a true understanding of how organized molecular pathways and networks give rise to normal and pathological cellular and organismal phenotypes will require more than large, experimentally derived data sets. Once again, computational investigation will be essential (Box 3), and there will be a greatly increased need for the collection, storage and display of the data in robust databases. By modelling specific pathways and networks, predicting how they affect phenotype, testing hypotheses derived from these models and refining the models based on new experimental d...
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