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The study of inter-species sequence comparisons is important for identifying functional elements in the genome (see Grand
Challenge I-1). Beyond this illuminating
role, determining the sequence differences
between species will provide insight into
the distinct anatomical, physiological and
developmental features of different organisms, will help to define the genetic basis for
speciation and will facilitate the characterization of mutational processes. This last
point deserves particular attention, because
mutation both drives long-term evolutionary change and is the underlying cause of
inherited disease. The recent finding that
mutation rates vary widely across the mammalian genome11 raises numerous questions
about the molecular basis for these evolutionary changes. At present, our understanding of DNA mutation and repair, including
the important role of environmental factors,
Genomics will provide the ability to substantively advance insight into evolutionary
variation, which will, in turn, yield new
insights into the dynamic nature of genomes
in a broader evolutionary framework.
Grand Challenge I-5 D e v e l o p p o li c y
o p t i o n s t h a t f a c ili t a t e t h e w i d e s p re a d u s e
o f g e n o m e i n f o r m a t i o n i n b o t h re s e a rc h
a n d c li n i c a l s e t t i n g s
Realization of the opportunities provided by
genomics depends on effective access to the BOX 4 Training
M e e tin g t h e s c i e n tifi c , m e d i c a l a n d
s o c...
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- Fall '14
- The Tempest