Unformatted text preview: medical
research require new technological and
methodological developments before pilots
and then large-scale approaches can be
attempted. Recognizing that technology
development is an expensive and high-risk
undertaking, the NHGRI is nevertheless
committed to supporting and fostering technology development in many of these crucial
areas, including the following.
DNA sequencing. There is still great
opportunity to reduce the cost and increase
the throughput of DNA sequencing, and to
make rapid, cheap sequencing available
more broadly. Radical reduction of sequencing costs would lead to very different
approaches to biomedical research.
Genetic variation. Improved genotyping
methods and better mathematical methods
are necessary to make effective use of information about the structure of variation in
the human genome for identifying the
genetic contributions to human diseases and
other complex traits.
The genome ‘parts list’. Beyond coding
sequences and transcriptional units, new
computational and experimental approaches
are needed to allow the comp...
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