collins_genomicsNature2003

Determine how the genome encoded components function

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Unformatted text preview: atalogue of all of the components encoded in the human genome. ◆ Determine how the genome-encoded components function in an integrated manner to perform cellular and organismal functions. ◆ Understand how genomes change and take on new functional roles. Grand Challenge I-1 C o m p re h e n s i v e l y i d e n t i f y t h e s tru c t ur a l a n d f u n c t i o n a l c o m p o n e nt s e n c o d e d in t h e h u m a n g enom e Although DNA is relatively simple and well understood chemically, the human genome’s structure is extraordinarily complex and its function is poorly understood. Only 1–2% of its bases encode proteins7, and the full complement of protein-coding sequences still remains to be established. A roughly equivalent amount of the non-coding portion of the genome is under active selection11, suggesting that it is also functionally important, yet vanishingly little is known about it. It NATURE | VOL 422 | 24 APRIL 2003 | www.nature.com/nature probably contains the bulk of the regulatory information controlling the expression of the approximately 30,000 protein-coding genes, and myriad other functional elements, such as non-p...
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This document was uploaded on 04/02/2014.

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