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Unformatted text preview: atalogue of all of the
components encoded in the human
◆ Determine how the genome-encoded
components function in an integrated
manner to perform cellular and
◆ Understand how genomes change and
take on new functional roles.
Grand Challenge I-1 C o m p re h e n s i v e l y
i d e n t i f y t h e s tru c t ur a l a n d f u n c t i o n a l
c o m p o n e nt s e n c o d e d in t h e h u m a n
g enom e
Although DNA is relatively simple and well
understood chemically, the human genome’s
structure is extraordinarily complex and its
function is poorly understood. Only 1–2% of
its bases encode proteins7, and the full complement of protein-coding sequences still
remains to be established. A roughly equivalent amount of the non-coding portion of
the genome is under active selection11, suggesting that it is also functionally important,
yet vanishingly little is known about it. It
NATURE | VOL 422 | 24 APRIL 2003 | www.nature.com/nature probably contains the bulk of the regulatory
information controlling the expression of
the approximately 30,000 protein-coding
genes, and myriad other functional elements, such as non-p...
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This document was uploaded on 04/02/2014.
- Fall '14
- The Tempest