Unformatted text preview: rotein-coding genes
and the sequence determinants of chromosome dynamics. Even less is known about the
function of the roughly half of the genome
that consists of highly repetitive sequences or
of the remaining non-coding, non-repetitive
The next phase of genomics is to catalogue, characterize and comprehend the
entire set of functional elements encoded in
the human and other genomes. Compiling
this genome ‘parts list’ will be an immense
challenge. Well-known classes of functional elements, such as protein-coding sequences,
still cannot be accurately predicted from
sequence information alone. Other types of
known functional sequences, such as genetic
regulatory elements, are even less well
understood; undoubtedly new types remain
to be defined, so we must be ready to investigate novel, perhaps unexpected, ways in
which DNA sequence can confer function.
Similarly, a better understanding of epigenetic changes (for example, methylation
and chromatin remodelling) is needed to
comprehend the full repertoire of ways in
which DNA can encode information.
Comparison of genome sequences from
evolutionarily diverse species has emerg...
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