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For example the discovery of variants that correlate

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Unformatted text preview: ants that affect risk for disease could potentially be used in individualized preventive medicine — including diet, exercise, lifestyle and pharmaceutical intervention — to maximize the likelihood of staying well. For example, the discovery of variants that correlate with successful outcomes of drug therapy, or with unfortunate side effects, could potentially be rapidly translated into clinical practice. Turning this vision into reality will require the following: (1) unbiased determination of the risk associated with a particular gene variant, often overestimated in initial studies31; (2) technological advances to reduce the cost of genotyping (Box 2; see ‘Quantum leaps’, below); (3) research on whether this kind of personalized genomic information will actually alter health behaviours (see Grand Challenge II-5); (4) oversight of the implementation of genetic tests to ensure that only those with demonstrated clinical validity are applied outside of the research setting (Box 5); and (5) education of healthcare professionals and the public to be well-infor...
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