collins_genomicsNature2003

Grand challenge i 3 d e v e l o p a d e t a il e d u

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Unformatted text preview: ata, it should be possible to understand more completely the difference between a ‘bag of molecules’ and a functioning biological system. Grand Challenge I-3 D e v e l o p a d e t a il e d u n d e r s t a n d i n g o f t h e h e ri t a b l e v a ri a t i o n i n th e hum a n g e no m e Genetics seeks to correlate variation in DNA sequence with phenotypic differences (traits). The greatest advances in human genetics have been made for traits associated with variation in a single gene. But most phenotypes, including common diseases and variable responses to pharmacological agents, have a more complex origin, involving the interplay between multiple genetic factors (genes and their products) and nongenetic factors (environmental influences). Unravelling such complexity will require both a complete description of the genetic variation in the human genome and the development of analytical tools for using that information to understand the genetic basis of disease. Establishing a catalogue of all common variants in the human population, including...
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This document was uploaded on 04/02/2014.

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