This preview shows page 1. Sign up to view the full content.
Unformatted text preview: ata, it should be
possible to understand more completely the
difference between a ‘bag of molecules’ and a
functioning biological system.
Grand Challenge I-3 D e v e l o p a d e t a il e d
u n d e r s t a n d i n g o f t h e h e ri t a b l e v a ri a t i o n i n
th e hum a n g e no m e
Genetics seeks to correlate variation in DNA
sequence with phenotypic differences
(traits). The greatest advances in human
genetics have been made for traits associated
with variation in a single gene. But most
phenotypes, including common diseases
and variable responses to pharmacological
agents, have a more complex origin, involving the interplay between multiple genetic
factors (genes and their products) and nongenetic factors (environmental influences).
Unravelling such complexity will require
both a complete description of the genetic
variation in the human genome and the
development of analytical tools for using
that information to understand the genetic
basis of disease.
Establishing a catalogue of all common
variants in the human population, including...
View Full Document
This document was uploaded on 04/02/2014.
- Fall '14
- The Tempest