Grand challenge ii 5 in v e s t i g a t e h o w g e n

Unformatted text preview: mics to reveal the biology of more common disorders and developing more effective treatments for them (in the way that, for example, the search for compounds that target the presenilins has led to general therapeutic strategies for late-onset Alzheimer’s disease36). Grand Challenge II-5 In v e s t i g a t e h o w g e n e t i c ri s k i n f o r m a t i o n i s c o n v e y e d i n c li n i c a l s e t t i n g s , h o w t h a t i n f or m a t i o n i n f l u e n c e s h e a l t h s tr a t e g i e s a n d b e h a v i o u r s , a n d h o w t h e s e a ff e c t h e a l t h out c o m e s a n d c osts Understanding how genetic factors affect health is often cited as a major goal of genomics, on the assumption that applying such understanding in the clinical setting will improve health. But this assumption actually rests on relatively few examples and data, and more research is needed to provide sufficient guidance about how to use genomic information optimally for improving individual or public health. Theoretically, the steps by which genetic risk information would lead to improved health are: (1) an individual obtains genome-based i...
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