Unformatted text preview: mics to reveal the biology of more
common disorders and developing more
effective treatments for them (in the way
that, for example, the search for compounds
that target the presenilins has led to general
therapeutic strategies for late-onset
Alzheimer’s disease36).
Grand Challenge II-5 In v e s t i g a t e h o w
g e n e t i c ri s k i n f o r m a t i o n i s c o n v e y e d i n
c li n i c a l s e t t i n g s , h o w t h a t i n f or m a t i o n
i n f l u e n c e s h e a l t h s tr a t e g i e s a n d
b e h a v i o u r s , a n d h o w t h e s e a ff e c t h e a l t h
out c o m e s a n d c osts
Understanding how genetic factors affect
health is often cited as a major goal of
genomics, on the assumption that applying
such understanding in the clinical setting will
improve health. But this assumption actually
rests on relatively few examples and data, and
more research is needed to provide sufficient
guidance about how to use genomic information optimally for improving individual or
public health.
Theoretically, the steps by which genetic
risk information would lead to improved
health are: (1) an individual obtains
genome-based i...
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- Fall '14
- Genetics, DNA, The Tempest, Human genome, RO
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