collins_genomicsNature2003

Grand challenge ii 6 d e v e l o p g e n o m e b a s

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Unformatted text preview: s, but high-quality research of this sort could provide important guidance in clinical decisionmaking — as the work of several disciplines has already been helpful in caring for people with an increased risk of colon cancer as a result of mutations in FAP or HNPCC 37. Grand Challenge II-6 D e v e l o p g e n o m e b a s e d t o o l s t h a t i m p ro v e t h e h e a l t h o f a l l Disparities in health status constitute a significant global issue, but can genome-based approaches to health and disease help to reduce this problem? Social and other environmental factors are major contributors to health disparities; indeed, some would question whether heritable factors have any significant role. But population differences in allele frequencies for some disease-associated variants could be a contributing factor to certain disparities in health status, so incorporating this information into preventive and/or public-health strategies would be beneficial. Research is needed to understand the relationship between genomics and health disparities by rigorou...
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