collins_genomicsNature2003

High throughput approaches to identify them box 2

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Unformatted text preview: n of functional elements that do not encode protein (for example, regulatory regions and non-coding RNA sequences). High-throughput approaches to identify them (Box 2) will be needed to generate the experimental data that will be necessary to develop, confirm and enhance computational methods for detecting functional elements in genomes. Because current technologies cannot yet identify all functional elements, there is a need for a phased approach in which new methodologies are developed, tested on a pilot scale and finally applied to the entire human genome. Along these lines, the NHGRI recently launched the Encyclopedia of DNA Elements (ENCODE) Project (www.genome.gov/Pages/Research/ ENCODE) to identify all the functional elements in the human genome. In a pilot project, systematic strategies for identifying all functionally important genomic elements will be developed and tested using a selected 1% of the human genome. Parallel projects involving well-studied model organisms, for example, yeast, nematode and fruitfly, are ongo...
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This document was uploaded on 04/02/2014.

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