Unformatted text preview: n of functional elements that do not encode protein (for example, regulatory regions and non-coding RNA
sequences). High-throughput approaches
to identify them (Box 2) will be needed to
generate the experimental data that will be
necessary to develop, confirm and enhance
computational methods for detecting functional elements in genomes.
Because current technologies cannot
yet identify all functional elements, there is
a need for a phased approach in which
new methodologies are developed, tested
on a pilot scale and finally applied to the entire human genome. Along these lines,
the NHGRI recently launched the Encyclopedia of DNA Elements (ENCODE)
ENCODE) to identify all the functional
elements in the human genome. In a pilot
project, systematic strategies for identifying
all functionally important genomic elements will be developed and tested using a
selected 1% of the human genome. Parallel
projects involving well-studied model
organisms, for example, yeast, nematode and
fruitfly, are ongo...
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This document was uploaded on 04/02/2014.
- Fall '14
- The Tempest